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Perfil clínico-imunológico e avaliação da atividade de doença em pacientes com Doença de Sjögren: estudo observacional em centro de referência brasileiro

Thu, 12 Mar 2026 00:00:00 GMT

Title: Perfil clínico-imunológico e avaliação da atividade de doença em pacientes com Doença de Sjögren: estudo observacional em centro de referência brasileiro Abstract: Sjögren’s disease (SjD) is a systemic autoimmune condition characterized by chronic inflammation of exocrine glands and heterogeneous extraglandular manifestations. This study aimed to analyze the clinical, laboratory, and histopathological profile of patients with SjD followed at a tertiary referral center, as well as to explore the relationship between immunological markers, histological findings, and standardized indices of disease activity. This retrospective observational study was based on the review of medical records from patients treated at the Hospital de Clínicas of the Federal University of Uberlândia (HC-UFU). Demographic characteristics, diagnostic criteria, minor salivary gland biopsy findings, and validated indices of systemic disease activity and patient-reported symptoms were evaluated. The integrated analysis of these parameters allowed the characterization of disease behavior in the studied cohort and supported a discussion on the relative contribution of different diagnostic tools and assessment instruments in clinical practice. The findings highlight the multifaceted nature of Sjögren’s disease and reinforce the importance of a multidimensional approach for accurate diagnosis and appropriate management in specialized care settings.

Atividade muscular das regiões do pescoço e dorso, associada à dor musculoesquelética em estudantes universitários em contexto de ensino remoto

Mon, 09 Mar 2026 00:00:00 GMT

Title: Atividade muscular das regiões do pescoço e dorso, associada à dor musculoesquelética em estudantes universitários em contexto de ensino remoto Abstract: Introduction: Musculoskeletal pain (MSP) is associated with alterations in muscle function and may be related to postural and ergonomic demands imposed by academic activities. Objectives: This study aims to analyze the electromyographic activity of the cervical and lumbar regions in Nursing students with and without MSP and to correlate early and final academic activities of the course with MSP. Methodology: Thirty female students aged between 18 and 30 years were divided into four groups according to the year of the course: G1w/oP (1st year, without MSP, n=10), G1wP (1st year, with MSP, n=10), G5w/oP (5th year, without MSP, n=5), and G5wP (5th year, with MSP, n=5). Electromyographic activity of the trapezius and erector spinae muscles, bilaterally, was recorded during shoulder elevation and trunk extension, respectively, using surface electrodes and analyzed through the root mean square (RMS). Comparisons were performed between groups (G1 and G5) and between students with and without pain using Student’s t-test. Results: The mean normalized RMS (RMSn) values obtained from the trapezius and erector spinae muscles showed no statistically significant differences between G1 and G5, regardless of pain status or body side. However, slightly higher RMSn values were observed in fifth-year students with pain. Conclusions: Under the conditions evaluated, early and final academic activities were not associated with significant changes in the electromyographic activity of the upper trapezius and erector spinae muscles, regardless of the presence of MSP.

Evidências para o manejo da cardite reumática: síntese de revisões sistemáticas e desenvolvimento de protocolo assistencial sobre febre reumática

Tue, 16 Dec 2025 00:00:00 GMT

Title: Evidências para o manejo da cardite reumática: síntese de revisões sistemáticas e desenvolvimento de protocolo assistencial sobre febre reumática Abstract: Rheumatic fever is a highly prevalent disease, particularly among children, and one of its main complications, chronic rheumatic carditis, significantly impairs quality of life. This condition leads to frequent healthcare visits, financial burdens, disruptions in daily activities, hospitalizations, and, in severe cases, cardiac surgery or death. This study aimed to conduct an umbrella review (systematic review of systematic reviews) on therapeutic interventions for the prevention of chronic rheumatic carditis and its complications, with the purpose of developing a clinical care protocol to support pediatric management. Database searches were performed, followed by study selection and quality assessment, and the extracted data informed the development of the protocol in accordance with current guidelines. The findings indicate that the benefits of available treatments for preventing chronic rheumatic carditis and its complications remain uncertain, highlighting the need for further studies with robust methodologies to determine their effectiveness.

Efeito de uma estratégia de transição do cuidado baseada em videomonitoramento, teach-back e entrevista motivacional no autocuidado de pacientes com insuficiência cardíaca: ensaio clínico randomizado

Fri, 27 Feb 2026 00:00:00 GMT

Title: Efeito de uma estratégia de transição do cuidado baseada em videomonitoramento, teach-back e entrevista motivacional no autocuidado de pacientes com insuficiência cardíaca: ensaio clínico randomizado Abstract: Introduction: Heart failure (HF) is a complex clinical syndrome associated with high rates of hospitalization, mortality, and readmissions, often related to poor therapeutic adherence, fragmentation of care, and weaknesses during the transition between levels of the healthcare system. Structured care transition strategies, combined with the use of technologies such as video monitoring and behavior change methodologies, have been proposed as alternatives to strengthen self-care and reduce adverse outcomes. Objective: To evaluate the effectiveness of a structured hospital-to-primary care transition strategy, combined with remote clinical followup via video monitoring, grounded in motivational interviewing (MI) and teach-back (TB), on self-care in patients with HF, compared to usual care, over a 180-day follow-up period. Materials and Methods: This was a single-center randomized clinical trial with blinded outcome assessment, conducted with patients with decompensated HF and reduced ejection fraction (LVEF <40%), treated at the Hospital de Clínicas of the Federal University of Uberlândia. Participants were randomized into an intervention group (IG) and a control group (CG). At hospital discharge, the IG received an educational booklet, sharing of the discharge summary with primary care, and nursing consultations via video monitoring through WhatsApp® at 7, 30, 60, and 180 days post-discharge, using MI and TB, while the CG received usual care. The primary outcome was self-care, assessed using the European Self-Care Scale. Longitudinal analysis was performed using Generalized Estimating Equations (GEE), with models adjusted for age, sex, ejection fraction, and NYHA functional class, and analyses were conducted using R software. Results: A total of 140 patients were included (CG = 73; IG = 67), with a mean age of 65.59 ± 13.72 years in the CG and 63.94 ± 14.28 years in the IG, predominantly NYHA functional class II (n = 60; 42.9%), and a mean LVEF of 30.49 ± 6.49%. The GEE model adjusted for age, sex, LVEF, and NYHA functional class showed a significant interaction between group and time (χ² = 27.22; p < 0.001). Adjusted mean total self-care scores remained stable in the CG over time, whereas a progressive reduction in scores was observed in the IG (29.07 ± 0.92 at baseline, 24.38 ± 1.08 at 30 days, 19.84 ± 0.75 at 60 days, and 19.92 ± 0.90 at 180 days). Adjusted between-group differences (IG − CG) were −0.78 at baseline, −6.28 at 30 days, −9.32 at 60 days, and −10.09 points at 180 days, indicating a clinically and statistically significant improvement in self-care in the IG. Lower rates of readmission (32.14% vs. 11.76%) and mortality (5.36% vs. 1.96%) were also observed in the IG. Conclusions: The nurse-led care transition intervention, combining MI, TB, and clinical video monitoring, significantly improved self-care in patients with HF over 180 days, in addition to reducing readmissions and mortality, supporting the incorporation of these strategies into care transition models to enhance patient engagement and sustain self-care