https://repositorio.ufu.br/handle/123456789/5167 Alterada nomencatura do antigo Instituto de Genética e Bioquímica: Resolução 05/99 do Conselho Universitário 2026-08-08T10:02:19Z https://repositorio.ufu.br/handle/123456789/49366 Title: Avaliação in vitro de metabólitos termoestáveis de Bacillus spp. no controle da Macrophomina phaseolina 2026-03-13T00:00:00Z https://repositorio.ufu.br/handle/123456789/49363 Title: Avaliação do efeito anti-Leishmania de complexos ternários de rutênio(II)- p -cimeno contendo benzoiltrifluoroacetona e piridinas modificadas Abstract: Leishmaniasis is a parasitic disease caused by protozoa of the genus Leishmania, transmitted to humans and other mammals through the bite of infected female phlebotomine sand flies. Recognized by the World Health Organization as a neglected tropical disease, leishmaniasis remains a major public health concern and presents in different clinical forms, including cutaneous, mucocutaneous, and visceral leishmaniasis, the latter being potentially fatal if left untreated. Despite the currently available therapies, limitations such as toxicity, parasite resistance, and variable efficacy highlight the need for the development of new therapeutic alternatives. In this context, medicinal bioinorganic chemistry plays a key role in the discovery of novel drug candidates, with ruthenium complexes emerging as promising compounds due to their potential antileishmanial activity. Therefore, the present study aimed to evaluate the antileishmanial potential of two novel ruthenium(II) complexes by assessing their cytotoxic effects against promastigotes of Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, Leishmania (Viannia) guyanensis, and Leishmania (Leishmania) infantum, as well as their effects on the parasite–host cell interaction using Leishmania (Leishmania) amazonensis. 2026-07-14T00:00:00Z https://repositorio.ufu.br/handle/123456789/49325 Title: Extratos vegetais de Anemopaegma arvense e Jacaranda decurrens: quantificação de compostos fenólicos, atividade antimicrobiana, atividade antioxidante e aplicação na síntese verde de nanopartículas Abstract: The biodiversity of the Brazilian Cerrado represents a promising source of bioactive compounds with potential biotechnological applications. Among the native species of this biome, Anemopaegma arvense, popularly known as catuaba, and Jacaranda decurrens, known as carobinha, were selected. Both belong to the Bignoniaceae family and have a history of use in traditional medicine. Furthermore, scientific interest in studying plant extracts as sustainable alternatives in the biosynthesis of nanoparticles has been increasing, as this approach reduces the use of toxic reagents and makes processes more environmentally viable. Crude extracts were obtained from different parts of Anemopaegma arvense (leaves, roots, and fruits) and from the leaves of Jacaranda decurrens through dynamic maceration assisted by ultrasound, aiming to optimize the extraction of bioactive compounds. The analysis revealed a significant presence of phenolic compounds in all extracts, with emphasis on the leaves of Jacaranda decurrens, which showed the highest concentration. Among the parts of Anemopaegma arvense, the leaves demonstrated the highest content of these compounds, followed by the roots and, lastly, the fruits. In antioxidant assays, both by the ABTS radical scavenging method and by reducing power, a dose-dependent behavior was observed, with increased activity as extract concentration increased. The leaf extract of Jacaranda decurrens showed the best antioxidant performance, while the leaves and roots of Anemopaegma arvense also demonstrated relevant activity. Regarding antimicrobial activity, no significant results were observed under the evaluated conditions. However, the biosynthesis of gold nanoparticles was successfully achieved, demonstrating the ability of the extracts to act as reducing and stabilizing agents. The results highlight the biotechnological value of Cerrado species, especially concerning antioxidant activity and their application in sustainable nanoparticle synthesis processes, in addition to contributing to the scientific knowledge and application of these native plants. 2026-03-12T00:00:00Z https://repositorio.ufu.br/handle/123456789/49290 Title: Avaliação in silico de potenciais inibidores peptídicos derivados do transcriptoma da peçonha de Odontomachus chelifer contra alvos relacionados à doença de Alzheimer 2026-07-10T00:00:00Z