https://repositorio.ufu.br/handle/123456789/19157 2026-08-13T07:51:47Z https://repositorio.ufu.br/handle/123456789/49474 Title: Perfil clínico, laboratorial e transfusional de pacientes oncológicos ambulatoriais: análise de três anos em hospital público brasileiro Abstract: Cancer represents a major public health concern and is frequently associated with hematological alterations resulting from both the disease itself and the therapies employed. In this context, transfusion support and the evaluation of laboratory parameters play a central role in the clinical management of these patients. This study aimed to characterize the clinical, laboratory, and transfusional profile of outpatient cancer patients treated at a public hospital in Brazil. This was a retrospective observational study including 389 patients treated between January 2020 and December 2022. The population had a median age of 62 years, with a slight predominance of females (53%). Solid tumors accounted for 52.9% of cases, followed by lymphoid (31.4%) and myeloid neoplasms (15.4%). During the study period, a total of 677 units of blood components were transfused, predominantly red blood cells concentrates (81.4%), with a median of two units per patient. Anemia was the main indication for transfusion (74.1%). Laboratory evaluation revealed consistent hematological abnormalities, including increased red cell distribution width (RDW), suggesting significant erythrocyte morphological heterogeneity. Additionally, elevated neutrophil-to-lymphocyte ratio (NLR) and platelet-to- lymphocyte ratio (PLR) indicated the presence of systemic inflammation. In the transfusional analysis, patients with solid tumors showed a higher intensity of red blood cell transfusion, whereas those with hematological neoplasms exhibited a higher frequency of platelet transfusion. Notably, platelet transfusion intensity was higher in patients with solid tumors, while among hematological neoplasms, the lymphoid subgroup demonstrated a greater relative demand for this component. Irregular antibody positivity was identified in 4.1% of patients, with a predominance of alloantibodies from the Rh and Kell systems. The occurrence of transfusion reactions was low, with three events reported. In conclusion, outpatient cancer patients present a high transfusional demand, with distinct patterns according to the type of neoplasm, as well as laboratory findings consistent with systemic inflammation and erythropoietic dysregulation. These findings highlight the importance of individualized transfusion strategies and contribute to improving clinical care in this population. 2026-04-24T00:00:00Z https://repositorio.ufu.br/handle/123456789/49419 Title: Análise in silico e in vitro da interação da BthTX-I, uma PLA2 Lys-49 da peçonha de Bothrops jararacussu, com proteínas-alvo associadas à infecção por Toxoplasma gondii 2025-12-12T00:00:00Z https://repositorio.ufu.br/handle/123456789/49395 Title: Extratos de plantas do gênero Banisteriopsis como uma abordagem terapêutica inovadora contra o vírus chikungunya 2026-03-13T00:00:00Z https://repositorio.ufu.br/handle/123456789/49288 Title: Avaliação das respostas comportamentais tipo ansiosas em camundongos adultos após a intoxicação alcoólica em camundongos adolescentes. Abstract: Alcohol is one of the most widely consumed psychoactive substances in the world, and its abusive use constitutes an important public health problem, being associated with the development of Alcohol Use Disorder. Adolescence represents a particularly vulnerable period to the effects of ethanol due to intense changes in the central nervous system, involving brain maturation and alterations in systems related to inhibitory control, reward, and emotional regulation. Alcohol exposure during this stage may produce long-lasting behavioral changes, increasing susceptibility to psychiatric disorders, such as anxiety disorders. Therefore, the present study aimed to evaluate the effects of alcohol intoxication during adolescence on anxiety-related behaviors in adult C57BL/6J mice. The animals received 0.9% saline solution or ethanol (3.5 g/kg; i.p.) in four intoxication/abstinence cycles, consisting of three consecutive days of administration followed by three days of abstinence. In adulthood, the animals were subjected to the Social Interaction Test (SIT) and the Novelty-Suppressed Feeding Test (NSF), ethological models used to assess anxiety in rodents. In the overall analyses, no statistically significant differences were observed between the control and intoxicated groups in the evaluated parameters. However, when considering sex as a factor, a significant interaction between sex and treatment was observed in phase 2 of the Social Interaction Test, with reduced duration of contact with an unfamiliar animal in males previously exposed to ethanol during adolescence, an effect not observed in females. In the NSF test, no significant differences were found between groups. The results demonstrate that alcohol intoxication during adolescence did not promote broad alterations in anxiety-like behaviors in adulthood; however, it induced specific changes related to social interaction in males. These findings reinforce adolescence as a critical period of vulnerability to the effects of alcohol and highlight the importance of considering sex differences when investigating the behavioral consequences of early ethanol exposure. 2026-05-15T00:00:00Z