https://repositorio.ufu.br/handle/123456789/18218 2026-09-25T01:23:19Z https://repositorio.ufu.br/handle/123456789/50383 Title: Potencial terapêutico de diferentes marcas de neurotoxina botulínica para tratamento de dor orofacial em humanos: uma revisão da Literatura Abstract: Chronic orofacial pain, including temporomandibular disorders (TMDs), myofascial pain, trigeminal neuralgia, and occipital neuralgia, represents a frequent therapeutic challenge in clinical practice, often exhibiting limited responsiveness to conventional treatments. In this context, botulinum toxin type A (BTX-A) has emerged as a promising therapeutic alternative. However, despite the wide availability of different commercial formulations, there is still no standardization regarding dosages, treatment protocols, or conversion ratios among products, which may influence clinical outcomes. Therefore, this study conducted a comprehensive literature review using the PubMed, Scopus, Web of Science, EMBASE, LILACS, and Google Scholar databases to identify human clinical studies investigating the use of BTX-A for the management of orofacial pain. Animal studies, reviews, study protocols, commentaries, conference abstracts, and case reports were excluded. Following duplicate removal using EndNote Web and Rayyan platforms, 1,069 records underwent screening by two independent reviewers, resulting in 84 eligible articles for full-text assessment. After the final selection process, 32 studies were included for in-depth analysis. The findings suggest that different botulinum toxin type A formulations—including OnabotulinumtoxinA (Botox®), AbobotulinumtoxinA (Dysport®), IncobotulinumtoxinA (Xeomin®), as well as products such as Hengli®, Botulax®, LetibotulinumtoxinA, and LanbotulinumtoxinA—demonstrate significant efficacy in reducing pain intensity, improving Visual Analog Scale (VAS) scores, decreasing the frequency of painful episodes, and enhancing patients’ quality of life. The most frequently investigated conditions were myofascial pain and TMD (18 studies, 688 patients), trigeminal neuralgia (14 studies, 700 patients), and occipital neuralgia (2 studies, 14 patients). Efficacy was consistently observed, particularly in myofascial pain/TMD and trigeminal neuralgia, whereas evidence for occipital neuralgia, although promising, remains limited. Regarding safety, BTX-A exhibited a favorable profile, with adverse events generally being mild and transient. Reported side effects included dysphagia, speech difficulties, facial asymmetry, muscle weakness, as well as isolated cases of hematoma, local erythema, xerostomia, diplopia, and headache. In conclusion, botulinum toxin type A appears to be an effective and safe therapeutic option for the management of chronic orofacial pain, particularly myofascial pain/TMD and trigeminal neuralgia. Nevertheless, methodological heterogeneity, small sample sizes, and the lack of standardization among different formulations continue to limit the comparability of findings. Further randomized controlled trials with larger sample sizes and standardized treatment protocols are required to establish more robust evidence and support clinical guidelines. 2026-06-26T00:00:00Z https://repositorio.ufu.br/handle/123456789/50345 Title: Avaliação da atividade antimicrobiana de bactérias odontopatogênicas por meio da inserção de nióbio em dentifrício fluoretado Abstract: Dental caries is a multifactorial disease strongly associated with the presence of cariogenic bacteria, especially Streptococcus mutans, Streptococcus mitis, and Streptococcus oralis, which justifies the search for oral care products with potential antimicrobial activity. The incorporation of bioactive metals into dental biomaterials has been widely investigated as a strategy to enhance dental biofilm control, with niobium standing out due to its high chemical stability and potential antimicrobial activity. Nevertheless, studies systematically evaluating the antimicrobial effects of niobium-derived compounds against odontopathogenic bacteria remain scarce, particularly when these compounds are incorporated into fluoridated dentifrices, thereby justifying the present investigation. This study assessed the antimicrobial activity of seven distinct niobium-derived compounds, both in their pure form and when incorporated into a commercial toothpaste formulation, against selected odontopathogenic bacteria. The evaluations included the determination of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) using the broth microdilution assay, in addition to complementary analysis by the agar diffusion method. A selective inhibitory and bactericidal effect of the niobium compounds was observed against Streptococcus mitis and Streptococcus oralis, whereas Streptococcus mutans did not exhibit susceptibility at the tested concentrations. In the agar diffusion assay, the incorporation of 10% niobium pentoxide and niobium nitride into the commercial dentifrice resulted in increased inhibition zones against S. mitis compared with the dentifrice alone. However, these compounds did not enhance antimicrobial activity against S. mutans or S. oralis. These findings suggest species-dependent antimicrobial activity, indicating selective potential and the need for further investigations for clinical application. 2026-03-04T00:00:00Z https://repositorio.ufu.br/handle/123456789/50281 Title: Influência de materiais obliteradores nas propriedades ópticas, mecânicas e superficiais da dentina Abstract: Dentin hypersensitivity is a highly prevalent clinical condition characterized by short, sharp, and transient pain resulting from dentin exposure to thermal, tactile, evaporative, osmotic, or chemical stimuli. Despite the availability of different desensitizing agents, there is still no fully established protocol regarding the longevity and stability of these treatments. The objective of this study was to evaluate the influence of different obliterating materials on the topography and physicomechanical properties of dentin. For this purpose, 50 dentin slices obtained from the buccal surface of sound human molars were initially treated with 3% potassium nitrate associated with 5% glutaraldehyde and subsequently randomly allocated into five experimental groups (n=10): Group A: 3% potassium nitrate + 5% glutaraldehyde; Group B: 3% potassium nitrate + 5% glutaraldehyde + one layer of Universal Adhesive; Group C: 3% potassium nitrate + 5% glutaraldehyde + two layers of Universal Adhesive; Group D: 3% potassium nitrate + 5% glutaraldehyde + fluoride varnish; and Group E: 3% potassium nitrate + 5% glutaraldehyde + one layer of Universal Adhesive + Bulk Fill Flow resin. The specimens were evaluated immediately after material application, after coffee aging, and after simulated toothbrushing corresponding to 7, 30, 90, 180, and 360 days of clinical use. Color change, microhardness, and surface roughness analyses were performed, using appropriate statistical tests with a significance level of 5%. The results showed that Groups C and E presented greater color stability over time, whereas Groups C, D, and E maintained greater microhardness stability after the simulated erosive and abrasive challenges. Group E showed the highest surface roughness values, regardless of the evaluation period. It was concluded that the evaluated obliterating materials influenced the optical, mechanical, and surface properties of dentin, and that protocols involving multiple adhesive layers, fluoride varnish, and the association between universal adhesive and bulk fill flow resin demonstrated promising performance regarding the protection and longevity of dentin hypersensitivity treatment. 2026-07-01T00:00:00Z https://repositorio.ufu.br/handle/123456789/50021 Title: Relato de experiência da Liga Acadêmica de Odontologia em Saúde Coletiva (LIOSC) da UFU: impactos na formação acadêmica e profissional Abstract: Academic leagues are scientific organizations composed of university students, aimed at complementing academic training through extracurricular activities. The Academic League of Dentistry in Public Health (LIOSC) seeks to promote both theoretical and practical development in Public Health for students of the School of Dentistry at the Federal University of Uberlândia (FOUFU), as well as to create educational materials to provide health information to all social actors involved in extension activities. LIOSC also conducts activities at the Casa Santa Gemma institution, including health promotion, supervised tooth brushing, and risk assessment. Currently, LIOSC is composed of 13 students and 2 faculty members from FOUFU, who meet weekly to organize teaching and extension activities. Monthly, collective panels are held with invited speakers addressing relevant topics in Public Health. To disseminate health information to individuals circulating in Blocks 4LA and 4LB, posters containing a QR Code linking to an online informational booklet were placed on the entrance hall noticeboards of each block. This QR Code is also made available on Instagram for all followers of the League’s social media account. In this way, academic leagues further foster research, teaching, and extension among participating students, enhancing curricular academic development and consequently better preparing them for the labor market. Since its foundation, LIOSC has achieved significant results, producing informative health materials, promoting disease prevention and health promotion within the community, and carrying out extracurricular activities primarily aimed at FOUFU students. 2026-02-24T00:00:00Z