DSpace Collection:https://repositorio.ufu.br/handle/123456789/465832026-06-06T22:41:25Z2026-06-06T22:41:25ZPerfil clínico-imunológico e avaliação da atividade de doença em pacientes com Doença de Sjögren: estudo observacional em centro de referência brasileirohttps://repositorio.ufu.br/handle/123456789/487152026-05-23T06:23:01Z2026-03-12T00:00:00ZTitle: Perfil clínico-imunológico e avaliação da atividade de doença em pacientes com Doença de Sjögren: estudo observacional em centro de referência brasileiro
Abstract: Sjögren’s disease (SjD) is a systemic autoimmune condition characterized by chronic
inflammation of exocrine glands and heterogeneous extraglandular manifestations. This study
aimed to analyze the clinical, laboratory, and histopathological profile of patients with SjD
followed at a tertiary referral center, as well as to explore the relationship between
immunological markers, histological findings, and standardized indices of disease activity.
This retrospective observational study was based on the review of medical records from
patients treated at the Hospital de Clínicas of the Federal University of Uberlândia
(HC-UFU). Demographic characteristics, diagnostic criteria, minor salivary gland biopsy
findings, and validated indices of systemic disease activity and patient-reported symptoms
were evaluated. The integrated analysis of these parameters allowed the characterization of
disease behavior in the studied cohort and supported a discussion on the relative contribution
of different diagnostic tools and assessment instruments in clinical practice. The findings
highlight the multifaceted nature of Sjögren’s disease and reinforce the importance of a
multidimensional approach for accurate diagnosis and appropriate management in specialized
care settings.2026-03-12T00:00:00ZEvidências para o manejo da cardite reumática: síntese de revisões sistemáticas e desenvolvimento de protocolo assistencial sobre febre reumáticahttps://repositorio.ufu.br/handle/123456789/486412026-04-23T06:21:25Z2025-12-16T00:00:00ZTitle: Evidências para o manejo da cardite reumática: síntese de revisões sistemáticas e desenvolvimento de protocolo assistencial sobre febre reumática
Abstract: Rheumatic fever is a highly prevalent disease, particularly among children, and one of its main complications, chronic rheumatic carditis, significantly impairs quality of life. This condition leads to frequent healthcare visits, financial burdens, disruptions in daily activities, hospitalizations, and, in severe cases, cardiac surgery or death. This study aimed to conduct an umbrella review (systematic review of systematic reviews) on therapeutic interventions for the prevention of chronic rheumatic carditis and its complications, with the purpose of developing a clinical care protocol to support pediatric management. Database searches were performed, followed by study selection and quality assessment, and the extracted data informed the development of the protocol in accordance with current guidelines. The findings indicate that the benefits of available treatments for preventing chronic rheumatic carditis and its complications remain uncertain, highlighting the need for further studies with robust methodologies to determine their effectiveness.2025-12-16T00:00:00ZProtocolo assistencial para o manejo da síndrome do desconforto respiratório agudo em pediatria em unidade de terapia intensiva pediátricahttps://repositorio.ufu.br/handle/123456789/485802026-03-27T06:20:25Z2026-02-24T00:00:00ZTitle: Protocolo assistencial para o manejo da síndrome do desconforto respiratório agudo em pediatria em unidade de terapia intensiva pediátrica2026-02-24T00:00:00ZProtocolo de realização de gastrostomia em paciente pediátricohttps://repositorio.ufu.br/handle/123456789/485632026-03-24T06:26:45Z2026-01-29T00:00:00ZTitle: Protocolo de realização de gastrostomia em paciente pediátrico2026-01-29T00:00:00Z