https://repositorio.ufu.br/handle/123456789/19178 2026-10-09T13:32:38Z 2026-10-09T13:32:38Z https://repositorio.ufu.br/handle/123456789/50495 2026-10-01T06:29:33Z 2025-09-22T00:00:00Z

Title: Desenvolvimento e caracterização espectroscópica de biopolímeros de quitosana na presença de nanopartículas de produtos naturais para encapsulamento de alimentos minimamente processados Abstract: This study presents the development, spectroscopic and microbiological characterization of an edible coating with the potential to extend the shelf life of fresh and minimally processed foods. The formulation was based on a chitosan solution, a natural anthocyanin dye extracted from Tradescantia pallida purpurea, and carbon nanoparticles (CDots) obtained via green synthesis. The coating was produced by extracting the natural dye, preparing chitosan and gelatin solutions, and synthesizing nanoparticles, followed by characterization using absorbance and fluorescence spectroscopy and Fourier Transform Infrared Spectroscopy (FTIR). The resulting film was evaluated for antifungal and antibacterial activities, as well as visual appearance and durability when applied to food. The results demonstrated that the developed coating exhibits promising antioxidant and antimicrobial properties, contributing to the preservation and extension of the shelf life of minimally processed foods. Thus, this study reinforces the potential of biopolymers and natural pigments as sustainable alternatives to conventional packaging and for increasing shelf life, contributing to advancements in food preservation technologies.

2025-09-22T00:00:00Z https://repositorio.ufu.br/handle/123456789/50494 2026-10-01T06:29:21Z 2026-04-29T00:00:00Z

Title: Validação do potencial antineurodegenerativo do peptídeo P5LFM-BSB, em Drosophila melanogaster modelo de doença de Alzheimer Abstract: Alzheimer’s disease is the leading cause of dementia worldwide and represents one of the greatest public health challenges of the 21st century. It is characterized by the accumulation of β-amyloid peptide (Aβ) in brain tissue. Given the limitations of currently available treatments and the challenges associated with developing effective inhibitors of the enzyme BACE1, responsible for the rate-limiting step of the amyloidogenic pathway, the search for new bioactive molecules with neuroprotective potential becomes imperative. In this context, the present study investigated the antineurodegenerative potential of the synthetic peptide P5LFMBSB (Peptide 5 from the larval food microbiome of Brazilian stingless bees), derived from the secretome of bacteria isolated from the larval food of Brazilian stingless bees, using a transgenic Drosophila melanogaster line as a model of Alzheimer’s disease. To this end, peptide toxicity was assessed through eclosion and metamorphosis progression assays, as well as its effects on the neurodegenerative phenotype through qualitative and quantitative analyses of the fly eye surface, using scanning electron microscopy and the Flynotyper plugin. The experimental model was previously validated, showing significant disorganization of ommatidia in the ADlike genotype compared to the control line UAS-Aβ/+. The peptide P5LFM-BSB did not exhibit toxicity at the tested concentrations (25, 50, 100, and 200 µM), and treated groups showed a reduction in the degree of ommatidial disorganization compared to the untreated group, with a statistically significant difference at the 50 µM concentration. These results indicate that the peptide P5LFM-BSB exhibits antineurodegenerative activity when evaluated in a Drosophila melanogaster rough eye model, highlighting its potential as a promising molecule for the development of new therapeutic strategies for Alzheimer’s disease.

2026-04-29T00:00:00Z https://repositorio.ufu.br/handle/123456789/50151 2026-09-09T06:18:05Z 2026-08-13T00:00:00Z

Title: Produção de bebidas fermentadas a partir de polpas de açaí e de acerola: estudo de viabilidade e desenvolvimento do estudo Abstract: The production of fermented beverages from tropical fruits represents a promising alternative for adding value to raw materials, reducing post-harvest losses, and developing innovative products with functional potential. In this context, the present study aimed to develop a process for producing fermented drinks from açaí (Euterpe oleracea Mart.) and acerola (Malpighia emarginata) pulp, considering technical and economic aspects. Commercial fruit pulps were used to prepare the must, including adjustments of soluble solids and pH, followed by inoculation with Saccharomyces cerevisiae and alcoholic fermentation under controlled temperatures ranging from 20 to 25 °C for 20 to 30 days. After fermentation, racking, clarification, and centrifugation were performed to evaluate the visual characteristics of the fermented beverages. The results showed differences between the fermented drinks produced: the acerola fermented drink presented an orange-colored pellet and a clearer supernatant, whereas the açaí wine exhibited a dark purple pellet and lipid residues adhered to the centrifuge tube walls, a characteristic associated with the higher lipid content of the fruit. These findings demonstrate the influence of the physicochemical composition of the raw materials on the characteristics of the fermented beverages and indicate the feasibility of producing fermented drinks from tropical fruits, highlighting their potential for value addition, diversification of the fermented beverage market, and sustainable use of agricultural resources.

2026-08-13T00:00:00Z https://repositorio.ufu.br/handle/123456789/50094 2026-09-04T06:31:04Z 2026-05-18T00:00:00Z

Title: Avaliação de sistemas de drug delivery de 3-etoxicarbonila-2h-benzo[f]benzopiran-2-ona utilizando a simulação de dinâmica molecular

2026-05-18T00:00:00Z