https://repositorio.ufu.br/handle/123456789/18812 2026-08-22T10:33:13Z 2026-08-22T10:33:13Z https://repositorio.ufu.br/handle/123456789/49735 2026-08-22T06:26:25Z 2026-07-30T00:00:00Z

Title: Cremes hidratantes faciais anti-idade: uma revisão dos mecanismos de ação dos diferentes ativos disponíveis no mercado Abstract: Skin aging is a complex and inevitable biological process driven by intrinsic factors, such as genetics and metabolism, and extrinsic factors, with exposure to ultraviolet radiation (UV), pollution, and lifestyle standing out as the primary accelerators of extracellular matrix degradation. This study conducted a literature review on the process of cutaneous senescence and analyzed the efficacy of active ingredient classes, mechanisms of action, and formulations used to prevent and treat its signs. Skin physiology reveals that the depletion of structural components, such as collagen, elastin, and glycosaminoglycans, combined with the collapse of the calcium ion gradient, underlies the development of wrinkles and skin laxity. Analysis of the active ingredients demonstrated that the efficacy of these cosmeceuticals depends on crucial variables, such as active ingredient concentration, vehicle formulation, and chemical stability in the presence of oxidizing species. Anti-aging actives, including humectants, retinoids, alpha-hydroxy acids, peptides, and antioxidants, function through hydration, cell signaling, epidermal renewal, and free radical neutralization. However, many formulations require the combination of photoprotection and encapsulation technologies to maximize delivery and skin tolerability. Given the growing market driven by contemporary aesthetic pressures, the pursuit of anti-aging treatments should be grounded in a scientific understanding of their chemical mechanisms and conscious consumer choices, avoiding the unnecessary or inappropriate use of potent products while promoting skin health and consumer safety.

2026-07-30T00:00:00Z https://repositorio.ufu.br/handle/123456789/49430 2026-08-12T06:28:30Z 2026-03-17T00:00:00Z

Title: Suplementação esportiva sem cafeína: análise da composição química e da influência do efeito placebo sobre o desempenho físico Abstract: The consumption of pre-workout ergogenic aids has become established as a strategy for the acute optimization of physical performance. Traditionally, the effectiveness of these products is attributed to the presence of central nervous system stimulants. However, the indiscriminate use of these substances has been associated with significant toxicological risks, including epi- sodes of tachycardia and arrhythmias, especially among young individuals. Given this safety scenario, theexpansionofthemarketforstimulant-free(stim-free)formulationsraisesquestions regarding their actual effectiveness. The present study aimed to analyze the composition of these alternative formulations and investigate the influence of the psychobiological response on performance. The methodology consistedofanexploratoryliteraturereview. Itwasobservedthat, althoughtheinitialintention was to describe the chemical mechanisms of the placebo phenomenon, the current scientific literature prioritizes the analysis of clinical outcomes and experimental evidence. The results showed that the absence of stimulants is compensated by the action of cons- tituents such as creatine, beta-alanine, and L-citrulline, which are fundamental for energy resynthesis, vasodilation, and buffering of muscle acidosis. At the same time, experimental evi- denceindicatesthattheexpectationofefficacyiscapableofactivatingneurobiologicalpathways related to reward and pain modulation, thereby mimicking performance-enhancing effects. It is concluded that the efficacy of these formulations does not lie exclusively in pharmaco- logy, but in the combination of competent physiological substrates and applied sensory engine- ering strategies, validating the use of approaches that integrate metabolic and psychobiological processes.

2026-03-17T00:00:00Z https://repositorio.ufu.br/handle/123456789/49352 2026-08-08T06:23:38Z 2026-03-19T00:00:00Z

Title: Interação do azul de metileno-naftil-metil-piperazina com lipídio, proteína e células de câncer de pulmão: implicações para Terapia Fotodinâmica Abstract: Photodynamic therapy (PDT) has emerged as a promising alternative to conventional cancer treatments due to its selectivity and lower systemic toxicity. In this context, this study aimed to investigate the photochemical and biological properties of methylene blue derivatives, evaluating their potential application as photosensitizers in the treatment of lung cancer. Methylene blue (MB), its derivative containing a naphthyl-methyl-piperazine group (MB-NMP), and a synthesis intermediate (MB-I) were studied, with emphasis on the relationship between lipophilicity, interaction with biomolecules, and photodynamic activity. Initially, the photodegradation of the compounds under irradiation with red LED (λ = 633 nm) was evaluated, observing lower photodynamic stability for MB and MB-NMP compared to the intermediate AM-I. Lipophilicity was determined using the partition coefficient (LogP), showing a predominantly hydrophilic character for AM-NMP (LogP = -0.7 ± 0.4) and AM (LogP = -1.4 ± 0.3), although the derivative had a slightly higher lipophilicity than its precursor. Liposome binding assays corroborated this result, demonstrating a greater affinity of AM-NMP for lipid systems. The interaction with bovine serum albumin (BSA) was investigated by fluorescence spectroscopy, revealing binding constants on the order of 10³–10⁵ M⁻¹ and an approximate stoichiometry of 1:1, indicating moderate interaction and potential plasma transport capacity. Furthermore, photo-oxidation of BSA showed a faster decrease in fluorescence when in the presence of AM, suggesting faster degradation compared to the other compounds. When evaluating the incorporation rate in A549 cells, higher values were observed for AM-NMP, attributed to its greater lipophilicity. In MTT cell viability tests, the compounds did not show significant toxicity in the dark; however, under irradiation, AM and AM-NMP demonstrated significant phototoxic activity, while the intermediate AM-I did not show a satisfactory effect. The results show that structural modifications in methylene blue directly influence its photophysical properties, interaction with biomolecules, and photodynamic activity. The AM-NMP derivative stood out for its greater lipophilicity and cellular incorporation, and with photodynamic efficiency similar to that of AM. Thus, AM-NMP shows promise as a candidate for application in photodynamic therapy in lung cancer cells.

2026-03-19T00:00:00Z https://repositorio.ufu.br/handle/123456789/49067 2026-07-25T06:27:16Z 2026-03-05T00:00:00Z

Title: Cosméticos para esmaltação das unhas: uma revisão bibliográfica com ênfase em esmalte tradicional, acrílico e gel uv Abstract: Cosmetic products used for nail coating present complex formulations, composed of different classes of raw materials, selected to provide aesthetics, durability, and performance during application. Among the main products marketed, traditional nail polishes, acrylic systems, and UV-curable gels stand out, each differing in chemical composition, curing mechanism, and potential health risks. Conventional nail polishes are based on nitrocellulose, organic solvents, plasticizers, and pigments, remaining predominant in the market. In contrast, acrylic systems and UV gels use chemically or photo-activated (meth)acrylate monomers and oligomers, providing greater mechanical resistance to the coating. However, these formulations may trigger adverse effects, including allergic contact dermatitis, damage to the nail tissue, and photobiological risks associated with exposure to UV/LED lamps used for gel curing. Therefore, this literature review discusses chemical aspects, polymerization mechanisms, sanitary regulation, and potential toxicological implications, emphasizing the importance of safe application practices and professional qualification in handling these cosmetic products.

2026-03-05T00:00:00Z